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DE4338159A1. Germany. Doc. laid open (first ... About the decisive product parameters (mullite content and HBF) the patent does not contain any information.
The invention relates to methods and uses of modulating fetal hemoglobin expression (HbF) via BCL11A. [0010]. The invention is based, in part, upon ...
Thus, a promising approach is to pharmacologically inactivate a silencer(s) of fetal globin expression in order to re-activate HbF production in adult erythroid ...
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The invention relates to methods and uses of modulating fetal hemoglobin expression (HbF) via BCL11A. The invention is based, in part, upon identification of a ...
... hemoglobin is HbF. If individuals with beta mediterranean anemia also have concurrent HPFH, the expression of HbF may reduce the severity of the disease. In ...
the highly sequence specific disruption of the HbF silencing region which is mediated by the homing endonucleases disclosed herein, avoids off target effects at ...
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As used herein, the term “GOI” is an abbreviation of gene of interest. [0090]. As used herein, the term “HbF” is an abbreviation of fetal hemoglobin. [0091].
According to this hypothesis, other agents that can induce differentiation would also be expected to affect HbF production. ... Germany). Analysis of HbF ...
The addition of 620 ppm boric acid substantially improves the performance of the fuel cell, but 1230 ppm are ineffective. Similarly, 880 ppm HBF 4 substantially ...
According to this hypothesis, other agents that can induce differentiation would also be expected to affect HbF production. The focus here is on the efficacy of ...
In addition to its ability to bind gluatamine to form glutamine phenylacetate, phenylacetic acid (PAA) can induce tumor cells to undergo differentiation. (See ...
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it was shown that there is an odds ratio of 5 for having a less severe form of beta-thalassemia with the high-HbF variant (Galanello S. et al., 2009, Blood, in ...
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